Oedo wa Nemurenai!

Set in the early 18th century during Japan's Kyouhou era, the Kikugumi is a group formed by Usugumo, a courtesan from Yoshiwara's red light district, and consists of a thief named Kikunosuke, a doctor named Aoto Touichirou who practices Western medicine, and Usugumo's pet cat, Kotetsu. Usugumo's life is complicated due to her father being Tokugawa Yoshimune, the 8th Shogun of Japan, but their relationship is strained due to the power dynamics of the time. Aoto Touichirou and Kikunosuke join Usugumo in forming the Kikugumi, while a member of a mysterious group also sets their sights on Usugumo.