Arve Rezzle: Kikaijikake no Yousei-tachi

Remu Mikage learns his sister Shiki has uploaded her consciousness onto a computer using neural-linked nanomachines to study more efficiently at Okinotori-island's Mega Float City. Shiki's decision is complicated when the "Early Rapture" disaster occurs, putting those who've uploaded their consciousnesses at risk of coma or death. Remu discovers Shiki has survived by somehow retaining her digital form, but she now lacks memories of her family and past. The duo must evade a violent group of researchers while Shiki uses her newfound ability to control nanomachines.